diff --git a/src/flask/app.py b/src/flask/app.py
index 854a796e..3a4df366 100644
--- a/src/flask/app.py
+++ b/src/flask/app.py
@@ -1672,13 +1672,13 @@ class Flask(Scaffold):
 
             # a 3-tuple is unpacked directly
             if len_rv == 3:
-                rv, status, headers = rv
+                rv, status, headers = rv  # type: ignore[misc]
             # decide if a 2-tuple has status or headers
             elif len_rv == 2:
                 if isinstance(rv[1], (Headers, dict, tuple, list)):
                     rv, headers = rv
                 else:
-                    rv, status = rv
+                    rv, status = rv  # type: ignore[misc]
             # other sized tuples are not allowed
             else:
                 raise TypeError(
@@ -1701,7 +1701,11 @@ class Flask(Scaffold):
                 # let the response class set the status and headers instead of
                 # waiting to do it manually, so that the class can handle any
                 # special logic
-                rv = self.response_class(rv, status=status, headers=headers)
+                rv = self.response_class(
+                    rv,
+                    status=status,
+                    headers=headers,  # type: ignore[arg-type]
+                )
                 status = headers = None
             elif isinstance(rv, dict):
                 rv = jsonify(rv)
@@ -1729,13 +1733,13 @@ class Flask(Scaffold):
         # prefer the status if it was provided
         if status is not None:
             if isinstance(status, (str, bytes, bytearray)):
-                rv.status = status  # type: ignore
+                rv.status = status
             else:
                 rv.status_code = status
 
         # extend existing headers with provided headers
         if headers:
-            rv.headers.update(headers)
+            rv.headers.update(headers)  # type: ignore[arg-type]
 
         return rv
 
diff --git a/src/flask/helpers.py b/src/flask/helpers.py
index 84059319..fe47500e 100644
--- a/src/flask/helpers.py
+++ b/src/flask/helpers.py
@@ -186,7 +186,7 @@ def make_response(*args: t.Any) -> "Response":
         return current_app.response_class()
     if len(args) == 1:
         args = args[0]
-    return current_app.make_response(args)
+    return current_app.make_response(args)  # type: ignore
 
 
 def url_for(endpoint: str, **values: t.Any) -> str:
diff --git a/src/flask/typing.py b/src/flask/typing.py
index bd8e61dc..a839a7e4 100644
--- a/src/flask/typing.py
+++ b/src/flask/typing.py
@@ -4,14 +4,16 @@ import typing as t
 if t.TYPE_CHECKING:
     from _typeshed.wsgi import WSGIApplication  # noqa: F401
     from werkzeug.datastructures import Headers  # noqa: F401
-    from .wrappers import Response  # noqa: F401
+    from werkzeug.wrappers.response import Response  # noqa: F401
 
 # The possible types that are directly convertible or are a Response object.
 ResponseValue = t.Union[
     "Response",
-    t.AnyStr,
+    str,
+    bytes,
     t.Dict[str, t.Any],  # any jsonify-able dict
-    t.Generator[t.AnyStr, None, None],
+    t.Iterator[str],
+    t.Iterator[bytes],
 ]
 StatusCode = int