diff --git a/CHANGES.rst b/CHANGES.rst
index f7508afd..f70461ba 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -64,6 +64,8 @@ Unreleased
 -   When using the test client as a context manager (``with client:``),
     all preserved request contexts are popped when the block exits,
     ensuring nested contexts are cleaned up correctly. :pr:`3157`
+-   Show a better error message when the view return type is not
+    supported. :issue:`3214`
 
 .. _#2935: https://github.com/pallets/flask/issues/2935
 .. _#2957: https://github.com/pallets/flask/issues/2957
diff --git a/flask/app.py b/flask/app.py
index 76e45a30..654ee963 100644
--- a/flask/app.py
+++ b/flask/app.py
@@ -27,6 +27,7 @@ from werkzeug.exceptions import (
     default_exceptions,
 )
 from werkzeug.routing import BuildError, Map, RequestRedirect, RoutingException, Rule
+from werkzeug.wrappers import BaseResponse
 
 from . import cli, json
 from ._compat import integer_types, reraise, string_types, text_type
@@ -2063,7 +2064,7 @@ class Flask(_PackageBoundObject):
                 status = headers = None
             elif isinstance(rv, dict):
                 rv = jsonify(rv)
-            else:
+            elif isinstance(rv, BaseResponse) or callable(rv):
                 # evaluate a WSGI callable, or coerce a different response
                 # class to the correct type
                 try:
@@ -2071,11 +2072,18 @@ class Flask(_PackageBoundObject):
                 except TypeError as e:
                     new_error = TypeError(
                         "{e}\nThe view function did not return a valid"
-                        " response. The return type must be a string, tuple,"
+                        " response. The return type must be a string, dict, tuple,"
                         " Response instance, or WSGI callable, but it was a"
                         " {rv.__class__.__name__}.".format(e=e, rv=rv)
                     )
                     reraise(TypeError, new_error, sys.exc_info()[2])
+            else:
+                raise TypeError(
+                    "The view function did not return a valid"
+                    " response. The return type must be a string, dict, tuple,"
+                    " Response instance, or WSGI callable, but it was a"
+                    " {rv.__class__.__name__}.".format(rv=rv)
+                )
 
         # prefer the status if it was provided
         if status is not None:
diff --git a/tests/test_basic.py b/tests/test_basic.py
index 32803b8c..3351380b 100644
--- a/tests/test_basic.py
+++ b/tests/test_basic.py
@@ -1218,17 +1218,21 @@ def test_response_type_errors():
 
     with pytest.raises(TypeError) as e:
         c.get("/none")
-        assert "returned None" in str(e)
+
+    assert "returned None" in str(e)
 
     with pytest.raises(TypeError) as e:
         c.get("/small_tuple")
-        assert "tuple must have the form" in str(e)
+
+    assert "tuple must have the form" in str(e)
 
     pytest.raises(TypeError, c.get, "/large_tuple")
 
     with pytest.raises(TypeError) as e:
         c.get("/bad_type")
-        assert "it was a bool" in str(e)
+
+    assert "object is not callable" not in str(e)
+    assert "it was a bool" in str(e)
 
     pytest.raises(TypeError, c.get, "/bad_wsgi")