diff --git a/CHANGES.rst b/CHANGES.rst
index d400ef3e..6073e6a3 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -1,3 +1,10 @@
+Version 3.1.2
+-------------
+
+Unreleased
+
+- Respect ``autocorrect_location_header`` in ``make_response``. :issue:`5774`
+
 Version 3.1.1
 -------------
 
diff --git a/src/flask/app.py b/src/flask/app.py
index 1232b03d..ca7e59f5 100644
--- a/src/flask/app.py
+++ b/src/flask/app.py
@@ -1262,8 +1262,20 @@ class Flask(App):
             else:
                 rv.status_code = status
 
-        # extend existing headers with provided headers
         if headers:
+            headers = Headers(headers)
+            # Pop the Location header to handle it separately.
+            # This handles both "Location" and "location" keys.
+            location = headers.pop("Location", None) or headers.pop("location", None)
+
+            # If a Location header was found, set it using the response
+            # .location property. This respects the 'autocorrect_location_header'
+            # flag, which is the purpose of this fix.
+
+            if location is not None:
+                rv.location = location
+
+            # Add the remaining headers to the response.
             rv.headers.update(headers)
 
         return rv