diff --git a/CHANGES.rst b/CHANGES.rst
index 95a004d7..d31db61e 100644
--- a/CHANGES.rst
+++ b/CHANGES.rst
@@ -15,6 +15,7 @@ Unreleased
     -   The ``RequestContext.g`` property returning ``AppContext.g`` is
         removed.
 
+-   Update Werkzeug dependency to >= 2.2.
 -   The app and request contexts are managed using Python context vars
     directly rather than Werkzeug's ``LocalStack``. This should result
     in better performance and memory use. :pr:`4682`
diff --git a/setup.py b/setup.py
index bd31435c..7c53630d 100644
--- a/setup.py
+++ b/setup.py
@@ -4,7 +4,7 @@ from setuptools import setup
 setup(
     name="Flask",
     install_requires=[
-        "Werkzeug >= 2.2.0a1",
+        "Werkzeug >= 2.2.0",
         "Jinja2 >= 3.0",
         "itsdangerous >= 2.0",
         "click >= 8.0",